Review: pentoxifylline with standard compression treatment improves healing of venous leg ulcers.
نویسنده
چکیده
Data sources Published and unpublished studies in any language were identified by searching the Cochrane Wounds Group (which includes studies identified from Medline, CINAHL, and EMBASE/Excerpta Medica, and from hand searches of wound care journals and conference proceedings) and the Peripheral Vascular Disease Group trials registers (last searched May 2001); reviewing bibliographies of relevant publications; and contacting the drug manufacturer (Hoechst).
منابع مشابه
Pentoxifylline for treatment of venous leg ulcers: a systematic review.
INTRODUCTION Venous ulcers are usually treated with compression therapy, but, because this treatment may not be effective for some people, adjuvant therapy could be beneficial. We did a systematic review of randomised controlled trials that compared pentoxifylline (with and without compression treatment) with placebo, or other treatments, in patients with venous leg ulcers. METHODS We identif...
متن کاملRandomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers.
OBJECTIVE To determine whether pentoxifylline 400 mg (Trental 400) taken orally three times daily, in addition to ambulatory compression bandages and dressings, improves the healing rate of pure venous ulcers. DESIGN Randomised, double blind placebo controlled trial, parallel group study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and ...
متن کاملThe effect of pentoxifylline on chronic venous ulcers.
UNLABELLED Venous ulcers affect approximately 1% of the world's popula- tion, increasing health care expenditures and decreasing quality of life. Several hypotheses may help explain their origin. Insufficient veins or valves or impaired muscle function may lead to abnormal calf muscle pump function that can elevate ambulatory venous pressure. The aim of this study was to evaluate the efficacy o...
متن کاملOxpentifylline treatment of venous ulcers of the leg.
OBJECTIVE To determine the effect of oxpentifylline on the healing of venous ulcers of the leg. DESIGN Double blind, randomised, prospective, placebo controlled, parallel group study. SETTING Four outpatient clinics treating leg ulcers in England and the Republic of Ireland. PATIENTS 80 Consecutive patients with clinical evidence of venous ulceration of the leg in whom appreciable arteria...
متن کاملClinical Inquiry: What is the best initial treatment for venous stasis ulcers?
the mainstay of initial treatment of venous stasis ulcers is compression therapy (strength of recommendation [SOR]: A, systematic review of randomized controlled trials [RCTs]). Multicomponent compression therapy is slightly superior to single-component therapy (SOR: B, systematic review of RCTs with inconsistent results). The various types of dressings available for managing venous stasis ulce...
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ورودعنوان ژورنال:
- Evidence-based nursing
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2002